我们可以通过dll的PE Image File中指定位置的字节来判断dll文件是x86的还是x64的。如下是代码示例: public static ushort GetPEArchitecture(string pFilePath) { ushort architecture = 0; try { using (System.IO.FileStream fStream = new System.IO.FileStream(pFilePath, System.IO.FileMode.Open, System.IO.FileAccess.Read)) { using (System.IO.BinaryReader bReader = new System.IO.BinaryReader(fStream)) { if (bReader.ReadUInt16() == 23117) //check the MZ signature { fStream.Seek(0x3A, System.IO.SeekOrigin.Current); //seek to e_lfanew. fStream.Seek(bReader.ReadUInt32(), System.IO.SeekOrigin.Begin); //seek to the start of the NT header. if (bReader.ReadUInt32() == 17744) //check the PE\0\0 signature. { fStream.Seek(20, System.IO.SeekOrigin.Current); //seek past the file header, architecture = bReader.ReadUInt16(); //read the magic number of the optional header. } } } } } catch (Exception) { /* TODO: Any exception handling you want to do, personally I just take 0 as a sign of failure */} //if architecture returns 0, there has been an error. return architecture; }